Definition of de-

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de-

pref.

1. Do or make the opposite of; reverse: decriminalize.
2. Remove or remove from: delouse; deoxygenate.
3. Out of: deplane; defenestration.
4. Reduce; degrade: declass.
5. Derived from: deverbative.

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ETYMOLOGY:
Middle English de-, from Old French de- (from Latin d-, from, off, apart, away, down, out, completely, from d; see de- in Indo-European roots), or from Old French des-, out, off, apart, away, completely (from Latin dis-, dis-, and Latin d-)